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AbouttheNorthwestSymposiumforSystemsBiology This ebook is the proceedingsofthe Pacific Northwest nationwide Laboratory (PNNL) inaugural assembly of the Northwest Symposium for platforms Biology, held October 17 and 18,2002, in Richland, Washington. this is often the40thyear within which the laboratory has held an interdisciplinary technological know-how symposium to deal with very important biologicalquestions. Inyearspast, theunifyingthemewasenvironmentalsciences.This yearwebegananewseriesofsymposiaonsystemsbiology.Aparticularfocusofthese symposiawill beon identifyingcurrentbreakthroughtechnologiesand theirapplication toimportantmodelsystems. PNNLestablished theBiomolecularSystemsInitiative(BSI) toexploit the original andinnovativetechnologiesdevelopedhereatthelaboratory, especiallyattheWilliamR. Wiley Environmental Molecular Sciences Laboratory (EMSL). The BSI is a multidisciplinary examine software thatfocuses on theareasofresearch that would force biology within the post-genomic period. It combines state of the art features for top throughputproteomics, cellimaging, quantitativebiology, andcomputationalbiology. to appreciate advanced organic structures, scientists needs to collect exact knowledgeaboutcellsignaling, andabouthownetworksregulatecellfunctions.Thiswill requireanintegratedeffortacrossavarietyofresearchdisciplines: molecularandcellular biology, biochemistry, physics, arithmetic, and data technology. The BSI is operating to supply possibilities for scientists from varied disciplines to gatherand discusscell networksatallscalesaswell asapproachesforunderstandingthemolecular componentsofthesenetworks. The topic of this year's symposium was once the U.S. division ofEnergy's new Genomes to lifestyles (GTL) application. GTL has the eventual target of a primary, finished, andsystematicunderstandingoflife. In its preliminary implementation, GTL focusesonpost-genomicapproachestounderstanding ComplexMicrobialSystems ComputationalMethods MolecularMachines: Multiproteincomplexes GeneRegulatoryNetworks.

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