By Nathan Brown
Written with the training medicinal chemist in brain, this can be the 1st sleek instruction manual to systematically deal with the subject of bioisosterism.
As such, it presents a prepared reference at the ideas and techniques of bioisosteric alternative as a key software in preclinical drug development.
the 1st half offers an outline of bioisosterism, classical bioisosteres and common molecular interactions that must be considered,
whereas the second one half describes a couple of molecular databases as resources of bioisosteric id and explanation. The 3rd part
covers the 4 key methodologies for bioisostere id and alternative: physicochemical homes, topology, form, and overlays of
protein-ligand crystal buildings. within the ultimate half, numerous real-world examples of bioisosterism in drug discovery initiatives are discussed.
With its designated descriptions of databases, equipment and real-life case experiences, this is often tailored for busy business researchers with little time for studying, whereas last simply obtainable to amateur drug builders because of its systematic constitution and introductory part.
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