Focused on valuable anxious process (CNS) drug discovery efforts, this ebook educates drug researchers in regards to the blood-brain barrier (BBB) to allow them to have an effect on vital advancements in a single of the main major – and such a lot demanding – components of drug discovery.
• Written by way of international specialists to supply functional suggestions to extend mind penetration or reduce CNS side-effects
• Reviews state of the art in silico, in vitro, and in vivo instruments to evaluate mind penetration and complex CNS drug supply strategies
• Covers BBB body structure, medicinal chemistry layout rules, loose drug speculation for the BBB, and shipping mechanisms together with passive diffusion, uptake/efflux transporters, and receptor-mediated processes
• Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)
• Discusses case experiences of profitable CNS and non-CNS medications, classes realized and paths to the market
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