Microbiology

Download E-books Current Topics in Microbiology and Immunology, Volume 296, Molecular Mimicry: Infection Inducing Autoimmune Disease, 1st Edition PDF

By Michael B.A. Oldstone (Editor)

The conceptual foundation for molecular mimicry used to be first outlined within the early Eighties whilst monoclonal antibodies opposed to viruses have been additionally proven to react with non-viral host protein; as a consequence, measles virus phosphoprotein cross-reacted with host cellphone cytokeratin, herpes simplex virus sort 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, back on the clonal point, that T telephone clones opposed to proteins from quite a few infectious brokers additionally reacted with host antigenic determinants. The clonal contrast was once valuable for the preliminary definition of mimicry. no less than 30 years ahead of our preliminary description of molecular mimicry related to cross-reactions among quite a few microbes, at the polyclonal antibody point, streptococcus used to be believed to react with renal glomeruli, center and basal ganglia to account for the glomerulonephritis, center and valvular illness and chorea, respectively. even if, next study confirmed that the nephritis was once attributable to immune complicated deposits and the tissue harm they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal point was once exposed. accordingly, for either historic purposes and mechanistic figuring out, you need to offer facts for cross-reactivity on the clonal point to turn out that molecular mimicry exists.

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