By Ronald J. Tallarida Ph.D., Leonard S. Jacob M.D., Ph.D. (auth.)
This ebook is designed to fulfill the trendy want for a greater figuring out of drug-receptor interplay as utilized to the collection and interpretation of dose-response information. it really is an advent appropriate for any pupil who has had a primary direction in pharmacology. This publication is an extension of the pharmacology path into one zone of what's referred to now as molecular pharmacology. the fabric incorporated is an outgrowth of classes that we've got given lately to health-science scholars in numerous specialist faculties and universities. the realm of drug-receptor concept, even supposing only a a part of molecular phar macology, is already very large. One significant line of research is anxious with the chemical and structural nature of particular receptors and with efforts to isolate particular receptors. one other line of research is worried with the kinetic theories of drug-receptor interplay, the hassle there being to supply a basic idea that's appropriate to extensive sessions of substances. we've got selected to accommodate the latter. There are a number of purposes for our selection of issues. First, the knowledge is especially sensible; that's, it allows one to take advantage of thoroughly and always phrases corresponding to "efficacy," "partial agonist," "pure antagonist," "potency," "pA2'" etc., whilst describing drug motion. moment, many scholars fail to understand the variations in and the constraints of a few of the theories, starting with the classical concept of A. J. Clark, on as much as the very fresh allosteric theories.
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